Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242387 | 0.88 | MAPT (0.57) | OPRK1CHIAHSD11B1MAPTLMNA | |
| SCHEMBL29089138 | 0.85 | POLB (0.56) | OPRK1CHIAHSD11B1MAPTLMNA | |
| SCHEMBL2454645 | 0.84 | OPRK1 (0.57) | OPRK1CHIAHSD11B1MAPTLMNA | |
| SCHEMBL18394828 | 0.84 | USP2 (0.58) | OPRK1HSD11B1MAPTLMNAKMT2A | |
| SCHEMBL2456713 | 0.83 | PRMT1 (0.53) | OPRK1HSD11B1LMNAHTR3EHTR3B | |
| SCHEMBL12633125 | 0.82 | OPRK1 (0.56) | OPRK1CHIAHSD11B1MAPTLMNA | |
| SCHEMBL8812104 | 0.82 | NPSR1 (0.59) | OPRK1CHIAHSD11B1MAPTLMNA | |
| SCHEMBL7238361 | 0.80 | OPRK1 (0.56) | OPRK1CHIAHSD11B1MAPTLMNA | |
| SCHEMBL1578863 | 0.79 | MEN1 (0.45) | MAPTKMT2AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL12194226 | 0.79 | OPRK1 (0.53) | OPRK1CHIAHSD11B1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768669-A1 | PIPERAZINE AZASPIRO DERIVAVES | Pfizer Inc (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183636-A1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER INC. (US) | 2019-09-26 | — | — | WO | disclosed |