Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 2/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 15/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.46 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.43 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23333308 | 0.89 | ATF4 (0.54) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL21390178 | 0.89 | ATF4 (0.54) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| Hydrochloric Acid SCHEMBL23294630 | 0.87 | ATF4 (0.54) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL21390151 | 0.85 | ATF4 (0.55) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL21390322 | 0.80 | ATF4 (0.48) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL25963238 | 0.80 | ATF4 (0.53) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL23294722 | 0.79 | ATF4 (0.54) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL21390073 | 0.79 | ATF4 (0.54) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL21390171 | 0.79 | ATF4 (0.50) | ATF4SCN9ASCN10ASCN7AKCNH2 | |
| SCHEMBL21390070 | 0.79 | ATF4 (0.54) | ATF4SCN9ASCN10ASCN7AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768660-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | Denali Therapeutics Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183589-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | DENALI THERAPEUTICS INC. (US) | 2019-09-26 | — | — | WO | disclosed |