Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19568600 | 0.95 | ATF4 (0.57) | ATF4NPSR1 | |
| SCHEMBL21384535 | 0.84 | ATF4 (0.59) | ATF4ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL23294682 | 0.83 | ATF4 (0.56) | ATF4ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL20722058 | 0.82 | ATF4 (0.53) | ATF4ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL20992777 | 0.82 | ATF4 (0.56) | ATF4NPSR1 | |
| SCHEMBL19568218 | 0.82 | ATF4 (0.56) | ATF4NPSR1 | |
| SCHEMBL19566748 | 0.82 | ATF4 (0.56) | ATF4NPSR1 | |
| SCHEMBL22627606 | 0.82 | ATF4 (0.56) | ATF4NPSR1 | |
| SCHEMBL22628041 | 0.82 | ATF4 (0.56) | ATF4NPSR1 | |
| SCHEMBL19568817 | 0.82 | ATF4 (0.56) | ATF4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768660-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | Denali Therapeutics Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183589-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | DENALI THERAPEUTICS INC. (US) | 2019-09-26 | — | — | WO | disclosed |