Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381705 | 0.86 | CACNA1B (0.40) | — | |
| SCHEMBL23211893 | 0.83 | MMP13 (0.49) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL21384762 | 0.83 | MMP13 (0.49) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL21381686 | 0.82 | MEN1 (0.49) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL21381624 | 0.80 | MEN1 (0.47) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL7502246 | 0.78 | MEN1 (0.47) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL7502242 | 0.78 | MEN1 (0.47) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL23211714 | 0.77 | MMP13 (0.48) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL21381711 | 0.77 | MEN1 (0.48) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL7493221 | 0.77 | MEN1 (0.48) | MEN1KMT2ANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768684-A1 | OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019180185-A1 | OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-09-26 | — | — | WO | disclosed |