Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | CLPP | Q16740 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL20593231 | 0.92 | CLPP (0.40) | MEN1KMT2APRMT5C5AR1CLPP | |
| SCHEMBL21385436 | 0.76 | C5AR1 (0.42) | MEN1KMT2AC5AR1CLPPCYP1A2 | |
| SCHEMBL30767848 | 0.75 | KMT2A (0.53) | MEN1KMT2AC5AR1CLPPGAA | |
| SCHEMBL322777 | 0.75 | KMT2A (0.53) | MEN1KMT2AC5AR1CLPPGAA | |
| SCHEMBL2868214 | 0.74 | KMT2A (0.59) | MEN1KMT2AC5AR1CLPPGAA | |
| SCHEMBL14872729 | 0.74 | KMT2A (0.52) | MEN1KMT2AC5AR1CLPPCYP1A2 | |
| SCHEMBL1911807 | 0.74 | KMT2A (0.52) | MEN1KMT2AC5AR1CLPPCYP1A2 | |
| SCHEMBL1911808 | 0.74 | KMT2A (0.52) | MEN1KMT2AC5AR1CLPPCYP1A2 | |
| Trifluoroacetic Acid SCHEMBL20593344 | 0.74 | KMT2A (0.39) | MEN1KMT2AC5AR1CLPPGAA | |
| SCHEMBL2845073 | 0.72 | MKNK1 (0.54) | MEN1KMT2AC5AR1CLPPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745420-B2 | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-08-18 | — | — | US | disclosed |
| US-10421765-B2 | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421765-B2 | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase | ATR, DTYMK, CHEK1 | MEN1 3160/4885KMT2A 1160/4885PRMT5 810/4885 |
| US-10745420-B2 | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase | ATR, DTYMK, CHEK1 | MEN1 3160/4885KMT2A 1160/4885PRMT5 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.