SCHEMBL21386572

SCHEMBL21386572

COC(COC(=O)c1ccc(C2CCC(C)CC2)cc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ADRB2 P07550 2/20 0.39
ADRB1 P08588 2/20 0.39
ADRB3 P13945 2/20 0.39
ESR2 Q92731 1/20 0.38
GRIN2B Q13224 1/20 0.37
SLC1A5 Q15758 1/20 0.37
MAN2B1 O00754 3/20 0.36
NPY2R P49146 1/20 0.36
GAA P10253 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
FFAR1 O14842 1/20 0.36
BCHE P06276 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12731151 0.91 ALDH1A1 (0.40) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL21577516 0.91 ALDH1A1 (0.40) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL19557078 0.87 ALDH1A1 (0.46) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL21396315 0.87 ALDH1A1 (0.46) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL24173516 0.87 ALDH1A1 (0.39) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL15299019 0.86 ALDH1A1 (0.44) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL18118962 0.85 ALDH1A1 (0.40) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL12154328 0.85 ALDH1A1 (0.40) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL14015522 0.85 ESR2 (0.36) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1
SCHEMBL21182764 0.84 CYP2C9 (0.44) ALDH1A1MAPTSMN1; SMN2ADRB2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3543314-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2019-09-25 EP disclosed