Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 19/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756565 | 0.87 | FGFR4 (0.49) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL22840675 | 0.86 | FGFR4 (0.33) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL22451157 | 0.76 | FGFR4 (0.44) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL21756595 | 0.76 | FGFR4 (0.61) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL21756581 | 0.76 | FGFR4 (0.59) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL21756519 | 0.76 | FGFR4 (0.59) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL21386627 | 0.75 | FGFR4 (0.41) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL22451152 | 0.75 | FGFR4 (0.41) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL23135909 | 0.74 | FGFR4 (0.62) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 | |
| SCHEMBL21386628 | 0.74 | FGFR4 (0.62) | FGFR4FGFR1FGFR2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |