SCHEMBL21387362

SCHEMBL21387362

COCCSN1CC(c2nc(-c3ccc(F)c(NC(=O)c4cnc5ccccn45)c3)no2)C1

nearest known ligand 0.71

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21387358 0.93 KIT (0.75) KIT
SCHEMBL21387338 0.91 KIT (0.75) KIT
SCHEMBL14740220 0.88 KIT (0.81) KIT
SCHEMBL14739633 0.87 KIT (0.71) KIT
SCHEMBL21387416 0.87 KIT (0.82) KIT
SCHEMBL21387383 0.86 KIT (0.76) KIT
SCHEMBL21387457 0.85 KIT (0.72) KIT
SCHEMBL21387397 0.85 KIT (0.82) KIT
SCHEMBL21387470 0.85 KIT (0.76) KIT
SCHEMBL14739802 0.85 KIT (0.76) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed