SCHEMBL21387433

SCHEMBL21387433

Cc1ccc(-c2noc(C3CN(SC4CCOC4)C3)n2)cc1NC(=O)c1cnc2ccccn12

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14739624 0.90 KIT (0.85) KIT
SCHEMBL21387398 0.88 KIT (0.82) KIT
SCHEMBL14739898 0.88 KIT (0.90) KIT
SCHEMBL21387314 0.88 KIT (0.81) KIT
SCHEMBL14740141 0.87 KIT (0.74) KIT
SCHEMBL27337264 0.86 KIT (0.87) KIT
SCHEMBL14739173 0.86 KIT (1.00) KIT
SCHEMBL21387479 0.86 KIT (0.78) KIT
SCHEMBL21387368 0.86 KIT (0.86) KIT
SCHEMBL21387504 0.85 KIT (0.80) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed