Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 3/20 | 0.54 |
| ▸ | BRD2 | P25440 | 2/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.54 |
| ▸ | TPH1 | P17752 | 6/20 | 0.48 |
| ▸ | TPH2 | Q8IWU9 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389530 | 0.92 | BRD4 (0.56) | MAPTNPSR1BRD4BRD2BRD3 | |
| SCHEMBL21389562 | 0.87 | MAPT (0.45) | MAPTNPSR1BRD4BRD2BRD3 | |
| SCHEMBL21389588 | 0.87 | BRD4 (0.56) | MAPTNPSR1BRD4BRD2BRD3 | |
| SCHEMBL21389561 | 0.86 | BRD4 (0.56) | BRD4BRD2BRD3TPH1TPH2 | |
| SCHEMBL23731052 | 0.86 | BRD4 (0.57) | MAPTNPSR1BRD4BRD2BRD3 | |
| SCHEMBL19090314 | 0.84 | BRD4 (0.56) | MAPTBRD4BRD2BRD3TPH1 | |
| SCHEMBL23731023 | 0.84 | BRD4 (0.55) | MAPTNPSR1BRD4BRD2BRD3 | |
| SCHEMBL21389556 | 0.83 | BRD4 (0.54) | MAPTBRD4BRD2BRD3TPH1 | |
| SCHEMBL21389515 | 0.80 | BRD4 (0.51) | MAPTNPSR1BRD4BRD2BRD3 | |
| SCHEMBL23730964 | 0.80 | BRD4 (0.51) | NPSR1BRD4BRD2BRD3TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-01-18 | — | — | US | disclosed |
| EP-3397640-B1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INST NAT SANTE RECH MED (FR) | 2021-08-04 | — | — | EP | disclosed |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | BET1, BRD4, BRD3 | MAPT 2558/4885NPSR1 4486/4885BRD4 2/4885 |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | BET1, BRD4, BRD3 | MAPT 2558/4885NPSR1 4486/4885BRD4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.