Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.57 |
| ▸ | BRD2 | P25440 | 2/20 | 0.57 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TPH1 | P17752 | 6/20 | 0.40 |
| ▸ | TPH2 | Q8IWU9 | 6/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389588 | 0.88 | BRD4 (0.56) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090314 | 0.88 | BRD4 (0.56) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL21389530 | 0.88 | BRD4 (0.56) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL23731023 | 0.87 | BRD4 (0.55) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL23730764 | 0.86 | BRD4 (0.47) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL21389556 | 0.86 | BRD4 (0.54) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL21389508 | 0.86 | MAPT (0.55) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL21389515 | 0.83 | BRD4 (0.51) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL21389561 | 0.83 | BRD4 (0.56) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL23730964 | 0.83 | BRD4 (0.51) | BRD4BRD2BRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3397640-B1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INST NAT SANTE RECH MED (FR) | 2021-08-04 | — | — | EP | disclosed |