Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | BRD2 | P25440 | 2/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.52 |
| ▸ | PNP | P00491 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641835 | 0.89 | PNP (0.60) | BRD4TLR7PNPHTTMEN1 | |
| SCHEMBL7676540 | 0.83 | BRD4 (0.51) | BRD4BRD2BRD3BRDTTLR7 | |
| SCHEMBL21389547 | 0.82 | TLR7 (0.51) | BRD4BRD2BRD3BRDTTLR7 | |
| SCHEMBL21389545 | 0.77 | BRD4 (0.62) | BRD4BRD2BRD3BRDTATM | |
| SCHEMBL13940893 | 0.77 | ADORA2B (0.60) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7681629 | 0.77 | PNP (0.80) | BRD4BRD2BRD3BRDTTLR7 | |
| SCHEMBL12233275 | 0.76 | ADORA2A (0.55) | LMNAHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL22105566 | 0.74 | BRD4 (0.59) | BRD4BRD2BRD3BRDTATM | |
| SCHEMBL4624542 | 0.72 | PNP (0.60) | BRD4TLR7PNPHTTMEN1 | |
| SCHEMBL18207673 | 0.72 | TLR7 (0.67) | TLR7TLR8TRAP1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-01-18 | — | — | US | disclosed |
| EP-3397640-B1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INST NAT SANTE RECH MED (FR) | 2021-08-04 | — | — | EP | disclosed |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | BET1, BRD4, BRD3 | BRD4 2/4885BRD2 6/4885BRD3 3/4885 |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | BET1, BRD4, BRD3 | BRD4 2/4885BRD2 6/4885BRD3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.