Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | ATF4 | P18848 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390177 | 0.84 | ATF4 (0.47) | SCN9ASCN7AKCNH2SCN5ASCN10A | |
| SCHEMBL21390071 | 0.84 | ATF4 (0.47) | SCN9ASCN7AKCNH2SCN5ASCN10A | |
| SCHEMBL25962360 | 0.84 | ATF4 (0.47) | SCN9ASCN7AKCNH2SCN5ASCN10A | |
| SCHEMBL23332744 | 0.77 | SCN9A (0.40) | SCN9ASCN7AKCNH2SCN5ASCN10A | |
| SCHEMBL23332817 | 0.77 | SCN9A (0.40) | SCN9ASCN7AKCNH2SCN5ASCN10A | |
| SCHEMBL25963964 | 0.77 | SCN9A (0.43) | SCN9A | |
| SCHEMBL21390182 | 0.77 | SCN9A (0.38) | SCN9ASCN7AKCNH2SCN5ASCN10A | |
| SCHEMBL23332874 | 0.75 | ATF4 (0.37) | SCN9ASCN7AKCNH2SCN5AATF4 | |
| SCHEMBL23333309 | 0.74 | SCN9A (0.33) | SCN9ASCN7AKCNH2SCN5AATF4 | |
| SCHEMBL23332898 | 0.73 | SCN9A (0.43) | SCN9ASCN7AKCNH2SCN5ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183589-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | DENALI THERAPEUTICS INC. (US) | 2019-09-26 | — | — | WO | disclosed |