Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 8/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.31 |
| ▸ | ESRRA | P11474 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390825 | 0.79 | HCAR1 (0.41) | HCAR1PDE2APDE10ACYP11B1CYP11B2 | |
| SCHEMBL18779216 | 0.77 | CSNK1D (0.39) | POLBAPEX1KARS1 | |
| SCHEMBL21354649 | 0.77 | RPS6KA3 (0.33) | HCAR1PDE2APDE10APOLBAPEX1 | |
| SCHEMBL30315405 | 0.77 | RPS6KA3 (0.33) | HCAR1PDE2APDE10APOLBAPEX1 | |
| SCHEMBL21354651 | 0.77 | RPS6KA3 (0.33) | HCAR1PDE2APDE10APOLBAPEX1 | |
| SCHEMBL18779222 | 0.76 | MCHR1 (0.35) | HCAR1POLBAPEX1KARS1ESR1 | |
| SCHEMBL26008138 | 0.76 | RPS6KA3 (0.33) | HCAR1POLBAPEX1KARS1ESR1 | |
| SCHEMBL21375474 | 0.73 | MCHR1 (0.33) | — | |
| SCHEMBL21354650 | 0.73 | MCHR1 (0.34) | PDE2APDE10ACYP11B1CYP11B2ACSS2 | |
| SCHEMBL21375044 | 0.73 | ALK (0.33) | CCR5POLBAPEX1KARS1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |