Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gw501516. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD known ✓ | Q03181 | 19/20 | 0.71 |
| ▸ | PPARA | Q07869 | 9/20 | 0.71 |
| ▸ | PPARG | P37231 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265434 | 1.00 | PPARD (0.71) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6265437 | 0.87 | PPARD (0.58) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6239544 | 0.86 | PPARD (0.83) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6235983 | 0.86 | PPARD (0.83) | PPARDPPARAPPARG | |
| SCHEMBL6265961 | 0.85 | PPARD (0.70) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| Gw501516 SCHEMBL29356729 | 0.84 | PPARD (1.00) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| Gw501516 SCHEMBL68714 | 0.84 | PPARD (1.00) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL3819065 | 0.84 | PPARD (1.00) | PPARDPPARAPPARG | |
| SCHEMBL5519969 | 0.83 | PPARD (0.98) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL3809841 | 0.83 | PPARD (0.65) | PPARDPPARAPPARGMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10426757-B2 | Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2019-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10426757-B2 | Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function | FABP2, ALPG, ALPI | PPARD 2842/4885PPARA 1257/4885PPARG 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.