Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 20/20 | 1.00 |
| ▸ | PPARA | Q07869 | 8/20 | 1.00 |
| ▸ | PPARG | P37231 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235983 | 0.91 | PPARD (0.83) | PPARDPPARAPPARG | |
| SCHEMBL4680724 | 0.90 | PPARD (0.82) | PPARDPPARAPPARG | |
| SCHEMBL5515760 | 0.90 | PPARD (0.82) | PPARDPPARAPPARG | |
| SCHEMBL6238041 | 0.88 | PPARD (1.00) | PPARDPPARAPPARG | |
| SCHEMBL6265434 | 0.84 | PPARD (0.71) | PPARDPPARAPPARG | |
| Gw501516 SCHEMBL21391885 | 0.84 | PPARD (0.71) | PPARDPPARAPPARG | |
| SCHEMBL6238213 | 0.84 | PPARD (1.00) | PPARDPPARAPPARG | |
| SCHEMBL5861681 | 0.84 | PPARD (0.72) | PPARDPPARAPPARG | |
| SCHEMBL3920736 | 0.83 | PPARD (0.71) | PPARDPPARAPPARG | |
| SCHEMBL3919912 | 0.83 | PPARD (0.71) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013134626-A1 | PREVENTION AND TREATMENT OF RESPIRATORY INFECTION WITH PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR DELTA AGONIST | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-12 | — | — | WO | claimed |
| EP-1189895-B1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2005-06-08 | — | — | EP | claimed |
| US-6710063-B1 | Activators of PPAR delta | SMITHKLINE BEECHAM CORPORATION | 2004-03-23 | — | — | US | claimed |
| US-20030077298-A1 | Activators and ligands of PPAR-beta/delta for the treatment of skin conditions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION | 2003-04-24 | — | — | US | claimed |
| WO-2002083131-A1 | ACTIVATORS AND LIGANDS OF PPAR-BETA/DELTA FOR THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-10-24 | — | — | WO | claimed |
| WO-2013134626-A1 | PREVENTION AND TREATMENT OF RESPIRATORY INFECTION WITH PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR DELTA AGONIST | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-12 | — | — | WO | disclosed |
| EP-1819681-B1 | 7-(2H-PYRAZOL-3-YL)-3,5-DIHYDROXY-HEPTANOIC ACID DERIVATIVES AS HMG CO-A REDUCTASE INHIBITORS FOR THE TREATMENT OF LIPIDEMIA | WARNER LAMBERT CO (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20090170852-A1 | NOVEL PYRAZOLE-BASED HMG CoA REDUCTASE INHIBITORS | PFIZER INC. | 2009-07-02 | — | — | US | disclosed |
| US-7446121-B2 | Pyrazole-based HMG CoA reductase inhibitors | PFIZER INC. (US) | 2008-11-04 | — | — | US | disclosed |
| US-20080227974-A1 | Novel Substituted Azetidinones | PFIZER INC. | 2008-09-18 | — | — | US | disclosed |
| WO-2008104875-A1 | OXAZOLIDINONES AS CHOLESTEROL ABSORPTION INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-09-04 | — | — | WO | disclosed |
| EP-1912937-A1 | NOVEL SUBSTITUTED AZETIDINONES | Warner-Lambert Company LLC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1189895-B1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6723740-B2 | ADMINISTERING THERAPEUTIC AMOUNT OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST TO LOWER TRIGLYCERIDES | SMITHKLINE BEECHAM CORPORATION | 2004-04-20 | — | — | US | disclosed |
| US-6710063-B1 | Activators of PPAR delta | SMITHKLINE BEECHAM CORPORATION | 2004-03-23 | — | — | US | disclosed |
| US-20030203947-A1 | Administration of a therapeutic amount of a 1,3-thiazole-5-yl methylsulfanyl or 1,3-oxazole-5-yl methylsulfanyl derivative to a patient for lowering triglycerides | CHAO ESTHER YU-HSUAN (US) | 2003-10-30 | — | — | US | disclosed |
| US-20030077298-A1 | Activators and ligands of PPAR-beta/delta for the treatment of skin conditions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION | 2003-04-24 | — | — | US | disclosed |
| WO-2002083131-A1 | ACTIVATORS AND LIGANDS OF PPAR-BETA/DELTA FOR THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-10-24 | — | — | WO | disclosed |
| EP-1189895-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXO GROUP LIMITED (GB) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001000603-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXO GROUP LIMITED (GB) | 2001-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170852-A1 | NOVEL PYRAZOLE-BASED HMG CoA REDUCTASE INHIBITORS | HMGCR, BPHL, CYP46A1 | PPARD 182/4885PPARA 123/4885PPARG 141/4885 |
| US-20030203947-A1 | Administration of a therapeutic amount of a 1,3-thiazole-5-yl methylsulfanyl or 1,3-oxazole-5-yl methylsulfanyl derivative to a patient for lowering triglycerides | PPARA, PPARD, PPARG | PPARD 2/4885PPARA 1/4885PPARG 3/4885 |
| US-20030077298-A1 | Activators and ligands of PPAR-beta/delta for the treatment of skin conditions | PPARG, PPARD, PPARA | PPARD 2/4885PPARA 3/4885PPARG 1/4885 |
| US-20080227974-A1 | Novel Substituted Azetidinones | APOB, PCSK9, CYP46A1 | PPARD 278/4885PPARA 695/4885PPARG 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.