Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13024178 | 0.74 | IDH1 (0.62) | IDH1THRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL21393695 | 0.67 | TRIM24 (0.38) | GAAALDH1A1 | |
| SCHEMBL13531456 | 0.67 | IDH1 (0.37) | IDH1THRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL2413275 | 0.60 | KDM4E (0.45) | IDH1TSHRKDM4EALDH1A1 | |
| SCHEMBL17770632 | 0.60 | IDH1 (0.59) | IDH1LMNAMAPTGAATSHR | |
| SCHEMBL13024189 | 0.60 | HDAC4 (0.70) | IDH1MAPTTHRBALDH1A1KMT2A | |
| SCHEMBL26538138 | 0.59 | BAZ2B (0.41) | MAPTTHRBKDM4EMEN1KMT2A | |
| SCHEMBL22724094 | 0.59 | IDH1 (0.40) | IDH1LMNAMAPTTSHRKDM4E | |
| SCHEMBL19491595 | 0.59 | — | — | |
| SCHEMBL11636187 | 0.58 | HPGD (0.47) | MAPTKDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |