⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21393940 | 0.81 | — | — | |
| SCHEMBL24373804 | 0.80 | — | — | |
| SCHEMBL25561109 | 0.74 | IRAK4 (0.34) | — | |
| SCHEMBL25899041 | 0.73 | — | — | |
| SCHEMBL21393954 | 0.72 | — | — | |
| SCHEMBL21393425 | 0.72 | IRAK4 (0.32) | — | |
| SCHEMBL24616556 | 0.72 | — | — | |
| SCHEMBL29593385 | 0.72 | RXRA (0.37) | — | |
| SCHEMBL21379252 | 0.72 | RXRA (0.37) | — | |
| SCHEMBL27376994 | 0.67 | IRAK4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3578560-B1 | QUINAZOLINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2021-11-10 | — | — | EP | disclosed |
| US-10774082-B2 | Quinazoline compound | ASTELLAS PHARMA INC. (JP) | 2020-09-15 | — | — | US | disclosed |
| US-20200140437-A1 | QUINAZOLINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2020-05-07 | — | — | US | disclosed |
| US-10556906-B2 | Quinazoline compound | ASTELLAS PHARMA INC. (JP) | 2020-02-11 | — | — | US | disclosed |
| US-20190292182-A1 | QUINAZOLINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-09-26 | — | — | US | disclosed |