Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RGS4 | P49798 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529533 | 0.80 | NAPRT (0.51) | MAPTALDH1A1KDM4ECMA1GSK3A | |
| SCHEMBL4769071 | 0.75 | ALDH1A1 (0.60) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL17264296 | 0.73 | CMA1 (0.49) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL4326119 | 0.72 | NAPRT (0.64) | MAPTALDH1A1GSK3AGSK3BMEN1 | |
| SCHEMBL31560451 | 0.70 | MAPT (0.72) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL29264845 | 0.70 | MAPT (0.67) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL4376098 | 0.70 | ALDH1A1 (0.57) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL4762572 | 0.69 | ALDH1A1 (0.63) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL18717737 | 0.69 | GSK3A (0.53) | MAPTALDH1A1KDM4EALOX15CMA1 | |
| SCHEMBL31370912 | 0.69 | P2RX4 (0.59) | MAPTALDH1A1KDM4ECMA1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |