Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21395000 | 0.92 | KDM4E (0.43) | NTRK1KDM4EMAPTTP53GCK | |
| SCHEMBL29929642 | 0.88 | GCK (0.48) | KDM4EMAPTTP53GCKRARA | |
| SCHEMBL21394990 | 0.88 | DEGS1 (0.41) | NTRK1GCKRARARARBRARG | |
| SCHEMBL21394550 | 0.88 | KDM4E (0.51) | NTRK1KDM4EMAPTGCKALDH1A1 | |
| SCHEMBL29353782 | 0.88 | KDM4E (0.51) | NTRK1KDM4EMAPTGCKALDH1A1 | |
| SCHEMBL29357606 | 0.87 | MAPT (0.44) | NTRK1KDM4EMAPTTP53GCK | |
| SCHEMBL21394480 | 0.87 | MAPT (0.44) | NTRK1KDM4EMAPTTP53GCK | |
| SCHEMBL21395123 | 0.86 | P2RX3 (0.43) | NTRK1KDM4ETP53ALDH1A1RAB9A | |
| SCHEMBL21394784 | 0.86 | GCK (0.44) | NTRK1KDM4EMAPTGCKRARG | |
| SCHEMBL29356925 | 0.86 | GCK (0.44) | NTRK1KDM4EMAPTGCKRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |