Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29358598 | 0.86 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL21394754 | 0.86 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL29442811 | 0.85 | SNCA (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL21394758 | 0.85 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL29357852 | 0.85 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL21394469 | 0.85 | SNCA (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL29355531 | 0.84 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL21394847 | 0.84 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL21394828 | 0.84 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL29357065 | 0.84 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |