SCHEMBL21395939

SCHEMBL21395939

Cn1cc(CCC(=O)O)c2c(-c3ccncc3)cccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CMA1 P23946 8/20 0.43
CTSG P08311 1/20 0.43
MCL1 Q07820 1/20 0.42
HTR2C P28335 4/20 0.40
HTR2B P41595 4/20 0.40
HTR2A P28223 3/20 0.40
PTGER1 P34995 1/20 0.40
PTGER4 P35408 1/20 0.40
PTGER3 P43115 1/20 0.40
PTGER2 P43116 1/20 0.40
HTT P42858 1/20 0.40
CCNC P24863 1/20 0.39
CDK8 P49336 1/20 0.39
NFATC1 O95644 1/20 0.39
GSK3B P49841 1/20 0.39
DYRK1A Q13627 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
PDE10A Q9Y233 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18509808 0.90 PTGER1 (0.50) CMA1CTSGHTR2CHTR2BHTR2A
SCHEMBL21392220 0.81 MCL1 (0.55) CMA1CTSGMCL1PTGER1PTGER4
SCHEMBL18029128 0.80 ALDH1A1 (0.44) CMA1HTTNFATC1GSK3BDYRK1A
SCHEMBL20119869 0.79 HTR2C (0.63) CMA1CTSGHTR2CHTR2BHTR2A
SCHEMBL21392216 0.79 CMA1 (0.64) CMA1CTSGHTR2CHTR2BHTR2A
SCHEMBL20120023 0.78 EGFR (0.41) MCL1HTTHDAC6
SCHEMBL18509533 0.78 MCL1 (0.51) CMA1CTSGMCL1HTR2CHTR2B
SCHEMBL20120027 0.78 CMA1 (0.47) CMA1CTSGHTR2CHTR2BHTR2A
SCHEMBL18509797 0.78 CMA1 (0.47) CMA1CTSGHTR2CHTR2BHTR2A
SCHEMBL18509674 0.78 CMA1 (0.47) CMA1CTSGHTR2CHTR2BHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019183358-A2 WHOLE CELL PROCESSES TO PRODUCE NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2019-09-26 WO disclosed