Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22440518 | 1.00 | ATM (0.41) | ATMNAMPTTSHRALOX15GPR119 | |
| SCHEMBL29832106 | 1.00 | ATM (0.41) | ATMNAMPTTSHRALOX15GPR119 | |
| SCHEMBL29832077 | 1.00 | ATM (0.41) | ATMNAMPTTSHRALOX15GPR119 | |
| SCHEMBL22054837 | 1.00 | ATM (0.41) | ATMNAMPTTSHRALOX15GPR119 | |
| SCHEMBL27193052 | 1.00 | ATM (0.41) | ATMNAMPTTSHRALOX15GPR119 | |
| SCHEMBL23902047 | 1.00 | ATM (0.41) | ATMNAMPTTSHRALOX15GPR119 | |
| SCHEMBL23046046 | 0.91 | NAMPT (0.40) | ATMNAMPTGPR119KDM1AMAPK1 | |
| SCHEMBL23046045 | 0.91 | NAMPT (0.40) | ATMNAMPTGPR119KDM1AMAPK1 | |
| SCHEMBL21940706 | 0.91 | NAMPT (0.40) | ATMNAMPTGPR119KDM1AMAPK1 | |
| SCHEMBL21940884 | 0.91 | NAMPT (0.40) | ATMNAMPTGPR119KDM1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441743-B2 | Spiro aromatic ring compound and use thereof | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2025-10-14 | — | — | US | disclosed |
| US-12331056-B2 | SHP2 phosphatase inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2025-06-17 | — | — | US | disclosed |
| CN-115916765-B | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2025-04-18 | — | — | CN | disclosed |
| EP-4506035-A2 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-02-12 | — | — | EP | disclosed |
| US-20240376119-A1 | SPIRO COMPOUND AND USE THEREOF | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2024-11-14 | — | — | US | disclosed |
| CN-113874363-B | Protein tyrosine phosphatase inhibitors | ARRAY生物制药公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-114341124-B | Protein tyrosine phosphatase inhibitors | ARRAY生物制药公司 | 2024-09-20 | — | — | CN | disclosed |
| US-12084447-B2 | SHP2 phosphatase inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2024-09-10 | — | — | US | disclosed |
| EP-3768668-B1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS INC (US) | 2024-08-28 | — | — | EP | disclosed |
| CN-113493440-B | Salt of nitrogen-containing heteroaromatic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2024-08-23 | — | — | CN | disclosed |
| WO-2020249079-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | 北京盛诺基医药科技股份有限公司 | 2020-12-17 | — | — | WO | disclosed |
| US-20200392128-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2020-12-17 | — | — | US | disclosed |
| US-10844079-B2 | Spiro aromatic ring compound and application thereof | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2020-11-24 | — | — | US | disclosed |
| US-20200317695-A1 | SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2020-10-08 | — | — | US | disclosed |
| EP-3712151-A1 | SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | Etern Biopharma (Shanghai) Co., Ltd. (CN) | 2020-09-23 | — | — | EP | disclosed |
| WO-2020156242-A1 | SHP2 INHIBITOR AND APPLICATION THEREOF | 贝达药业股份有限公司 | 2020-08-06 | — | — | WO | disclosed |
| WO-2020156243-A1 | SHP2 INHIBITOR AND APPLICATION THEREOF | 贝达药业股份有限公司 | 2020-08-06 | — | — | WO | disclosed |
| US-20200108071-A1 | IMIDAZOPYRIMIDINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-04-09 | — | — | US | disclosed |
| WO-2020063760-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2020-04-02 | — | — | WO | disclosed |
| WO-2019183367-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12084447-B2 | SHP2 phosphatase inhibitors and methods of use thereof | PTPRCAP, PTPN22, PTPN1 | ATM 1242/4885NAMPT 2309/4885TSHR 3144/4885 |
| US-20200108071-A1 | IMIDAZOPYRIMIDINE DERIVATIVES | DPYD, KRAS, ABL1 | ATM 466/4885NAMPT 288/4885TSHR 3277/4885 |
| US-12441743-B2 | Spiro aromatic ring compound and use thereof | PTPN1, PTPN11, PTPN5 | ATM 662/4885NAMPT 1364/4885TSHR 1373/4885 |
| US-20240376119-A1 | SPIRO COMPOUND AND USE THEREOF | ROR1, PTPN1, PTPN5 | ATM 770/4885NAMPT 1133/4885TSHR 2362/4885 |
| US-20200392128-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN5, PTPN1, PTPRJ | ATM 3041/4885NAMPT 2775/4885TSHR 2954/4885 |
| US-10844079-B2 | Spiro aromatic ring compound and application thereof | PTPN1, PTPN11, PTPN5 | ATM 564/4885NAMPT 1459/4885TSHR 1262/4885 |
| US-20200317695-A1 | SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | PTPN1, PTPN11, PTPN5 | ATM 564/4885NAMPT 1459/4885TSHR 1262/4885 |
| US-12331056-B2 | SHP2 phosphatase inhibitors and methods of use thereof | PTPRCAP, PTPN22, PTPN1 | ATM 1242/4885NAMPT 2309/4885TSHR 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.