Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940884 | 1.00 | NAMPT (0.40) | NAMPTMAPK1DDB1CRBNROCK2 | |
| SCHEMBL29505983 | 1.00 | NAMPT (0.40) | NAMPTMAPK1DDB1CRBNROCK2 | |
| SCHEMBL29506056 | 1.00 | NAMPT (0.40) | NAMPTMAPK1DDB1CRBNROCK2 | |
| SCHEMBL23046045 | 1.00 | NAMPT (0.40) | NAMPTMAPK1DDB1CRBNROCK2 | |
| SCHEMBL29506011 | 1.00 | NAMPT (0.40) | NAMPTMAPK1DDB1CRBNROCK2 | |
| SCHEMBL23046046 | 1.00 | NAMPT (0.40) | NAMPTMAPK1DDB1CRBNROCK2 | |
| SCHEMBL22054837 | 0.91 | ATM (0.41) | NAMPTMAPK1GPR119KDM4EPKM | |
| SCHEMBL22440518 | 0.91 | ATM (0.41) | NAMPTMAPK1GPR119KDM4EPKM | |
| SCHEMBL23902047 | 0.91 | ATM (0.41) | NAMPTMAPK1GPR119KDM4EPKM | |
| SCHEMBL21397495 | 0.91 | ATM (0.41) | NAMPTMAPK1GPR119KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3867238-B1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2020081848-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-04-23 | — | — | WO | disclosed |