SCHEMBL21397965

SCHEMBL21397965

c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc(-n4c5cc6c7ccccc7n(-c7ccccc7)c6cc5c5cccnc54)cc3)n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
TSHR P16473 1/20 0.47
CYP2C19 P33261 1/20 0.47
KDM4E B2RXH2 1/20 0.44
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
FEN1 P39748 1/20 0.40
PDE4A P27815 5/20 0.37
PDE4B Q07343 4/20 0.37
PDE4C Q08493 4/20 0.37
PDE4D Q08499 4/20 0.37
RXRA P19793 1/20 0.35
KMT2A Q03164 2/20 0.34
ABCG2 Q9UNQ0 1/20 0.34
MAPT P10636 1/20 0.34
PTK2B Q14289 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
PTGER4 P35408 1/20 0.34
LDHA P00338 1/20 0.34
PDE10A Q9Y233 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17349450 0.94 ALDH1A1 (0.49) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL17349257 0.94 ALDH1A1 (0.49) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL17348642 0.93 ALDH1A1 (0.46) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL18958704 0.93 ALDH1A1 (0.46) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL18958692 0.93 ALDH1A1 (0.46) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL17349381 0.93 ALDH1A1 (0.46) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL21007778 0.93 ALDH1A1 (0.45) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL21007777 0.93 ALDH1A1 (0.47) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL17124118 0.92 ALDH1A1 (0.50) ALDH1A1TSHRCYP2C19KDM4EATM
SCHEMBL26082285 0.92 ALDH1A1 (0.47) ALDH1A1TSHRCYP2C19KDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019179497-A1 ORGANIC COMPOUND WITH PYRIDINE AS CORE AND USE THEREOF 江苏三月光电科技有限公司 2019-09-26 WO disclosed