⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL3175331 | 0.77 | IDO1 (0.34) | — | |
| SCHEMBL1878100 | 0.77 | — | — | |
| SCHEMBL27643432 | 0.74 | — | — | |
| SCHEMBL28646468 | 0.74 | — | — | |
| SCHEMBL1819326 | 0.72 | — | — | |
| Water SCHEMBL10385981 | 0.70 | — | — | |
| Carbamic Acid SCHEMBL8107835 | 0.66 | ACHE (0.39) | — | |
| SCHEMBL20958122 | 0.65 | — | — | |
| Ethylenediamine SCHEMBL23064434 | 0.64 | — | — | |
| SCHEMBL2184363 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570416-B1 | Antiviral bisfuran derivative as hiv protease inhibitor and intermediates thereof | GILEAD SCIENCES INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-20130172295-A1 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-8431745-B2 | Process for preparation of HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| EP-2570416-A1 | Antiviral bisfuran derivative as hiv protease inhibitor and intermediates thereof | Gilead Sciences, Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-20120258935-A1 | PROCESS FOR PREPARATION OF HIV PROTEASE INHBITORS | GILEAD SCIENCES, INC. (US) | 2012-10-11 | — | — | US | disclosed |
| US-8173623-B2 | Process for preparation of HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110065631-A1 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC (US) | 2011-03-17 | — | — | US | disclosed |
| EP-1999133-A2 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2008-12-10 | — | — | EP | disclosed |
| US-20080004242-A1 | Process for preparation of HIV protease inhibitors | GILEAD SCIENCES, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007126812-A2 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2007-11-08 | — | — | WO | disclosed |