Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 6/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | TEK | Q02763 | 3/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | TACR3 | P29371 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502111 | 1.00 | LCK (0.54) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL14568148 | 1.00 | LCK (0.54) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5501169 | 0.86 | LCK (0.59) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5501448 | 0.86 | LCK (0.59) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL21402130 | 0.86 | LCK (0.59) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL21402117 | 0.84 | ROCK2 (0.52) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5497529 | 0.84 | ROCK2 (0.52) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL14568149 | 0.84 | ROCK2 (0.52) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5497196 | 0.81 | LCK (0.62) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL14715558 | 0.80 | TACR3 (0.52) | ROCK2ROCK1TACR3PAK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | claimed |