Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878445 | 0.87 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL21407449 | 0.85 | BACE1 (0.37) | BACE1DUTUSP14 | |
| SCHEMBL2628927 | 0.78 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL445394 | 0.78 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL445392 | 0.78 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL19974442 | 0.77 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL2466359 | 0.77 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL8293842 | 0.77 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL3412038 | 0.76 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE | |
| SCHEMBL14949338 | 0.76 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1PIK3R1PIK3CABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279019-A1 | BENZONORBORNADIENE DERIVATIVES AND REACTIONS THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2023-09-07 | — | — | US | disclosed |
| US-11560384-B2 | Benzonorbornadiene derivatives and reactions thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2023-01-24 | — | — | US | disclosed |
| US-20190300539-A1 | Benzonorbornadiene Derivatives and Reactions Thereof | UNIVERSITY OF UTAH | 2019-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190300539-A1 | Benzonorbornadiene Derivatives and Reactions Thereof | CBR3, CBR1, CNR1 | HSP90AA1 3979/4885HSP90AB1 3582/4885PIK3R1 1528/4885 |
| US-20230279019-A1 | BENZONORBORNADIENE DERIVATIVES AND REACTIONS THEREOF | CBR3, CBR1, CNR1 | HSP90AA1 3859/4885HSP90AB1 3403/4885PIK3R1 1191/4885 |
| US-11560384-B2 | Benzonorbornadiene derivatives and reactions thereof | CBR3, CBR1, CNR1 | HSP90AA1 3979/4885HSP90AB1 3582/4885PIK3R1 1528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.