Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phthalimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 2/20 | 0.54 |
| ▸ | CASP6 | P55212 | 2/20 | 0.54 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.54 |
| ▸ | CASP2 | P42575 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalimide SCHEMBL8421052 | 0.98 | GSK3B (0.65) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28193801 | 0.84 | GSK3B (0.79) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28946377 | 0.82 | GSK3B (0.75) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL5215747 | 0.80 | GSK3B (0.71) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL11703668 | 0.80 | GSK3B (0.71) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL27955087 | 0.80 | GSK3B (0.79) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL23063638 | 0.79 | GSK3B (0.88) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28619195 | 0.79 | GSK3B (0.88) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL29664386 | 0.79 | GSK3B (0.88) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL6244849 | 0.79 | GSK3B (0.88) | GSK3BCASP3CASP7CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807712-B2 | Hydrogenated norbornene ring-opened polymer, and method of producing the same | ZEON CORPORATION (JP) | 2023-11-07 | — | — | US | disclosed |
| EP-3778695-A1 | NORBORNENE RING-OPENING POLYMER HYDRIDE AND METHOD FOR PRODUCING SAME | Zeon Corporation (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-20200399422-A1 | HYDROGENATED NORBORNENE RING-OPENED POLYMER, AND METHOD OF PRODUCING THE SAME | ZEON CORPORATION (JP) | 2020-12-24 | — | — | US | disclosed |
| WO-2019188720-A1 | NORBORNENE RING-OPENING POLYMER HYDRIDE AND METHOD FOR PRODUCING SAME | 日本ゼオン株式会社 | 2019-10-03 | — | — | WO | disclosed |