Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SDHB | P21912 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | STAT1 | P42224 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30368827 | 1.00 | PIK3CG (0.38) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL22999073 | 0.84 | RXFP1 (0.38) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL14643154 | 0.78 | SDHB (0.49) | PTGS2PTGS1NR1H2NR1H3LMNA | |
| SCHEMBL25159546 | 0.77 | CCNE1 (0.55) | PTGS2PTGS1 | |
| SCHEMBL29699125 | 0.74 | SDHB (0.34) | PTGS2PTGS1LMNASDHBSTAT3 | |
| SCHEMBL24087394 | 0.72 | SDHB (0.39) | NR1H2NR1H3LMNASDHBSTAT3 | |
| SCHEMBL30810371 | 0.70 | CCNE1 (0.59) | PIK3CGPIK3CDPIK3CB | |
| SCHEMBL29698972 | 0.69 | NPY5R (0.40) | PTGS2PTGS1NR1H2NR1H3LMNA | |
| SCHEMBL29141591 | 0.69 | TLR9 (0.39) | NR1H2NR1H3LMNASDHBSTAT3 | |
| SCHEMBL30291160 | 0.68 | KDM5B (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435063-B2 | Nitrogen containing heterocycles as CDK12 inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-10-07 | — | — | US | disclosed |
| EP-3782986-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-10 | — | — | EP | disclosed |
| CN-111918863-B | Heterocyclic compounds | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| US-20230117295-A1 | NITROGEN CONTAINING HETEROCYCLES AS CDK12 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-04-20 | — | — | US | disclosed |
| US-11584737-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-02-21 | — | — | US | disclosed |
| US-20210363130-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-11-25 | — | — | US | disclosed |
| EP-3782986-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2021-02-24 | — | — | EP | disclosed |
| CN-111918863-A | Heterocyclic compounds | 武田药品工业株式会社 | 2020-11-10 | — | — | CN | disclosed |
| WO-2019189555-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117295-A1 | NITROGEN CONTAINING HETEROCYCLES AS CDK12 INHIBITORS | CDK1, CDK12, CDK15 | PIK3CG 1110/4885PIK3CD 974/4885PIK3CA 777/4885 |
| US-11584737-B2 | Heterocyclic compound | CDK12, CDK1, CDK15 | PIK3CG 866/4885PIK3CD 692/4885PIK3CA 529/4885 |
| US-20210363130-A1 | HETEROCYCLIC COMPOUND | CDK12, CDK1, CDK15 | PIK3CG 866/4885PIK3CD 692/4885PIK3CA 529/4885 |
| US-12435063-B2 | Nitrogen containing heterocycles as CDK12 inhibitors | CDK1, CDK12, CDK15 | PIK3CG 1110/4885PIK3CD 974/4885PIK3CA 777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.