Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766654 | 0.92 | DPP7 (0.47) | DPP7KMT2ACYP2D6CYP3A4HRH3 | |
| SCHEMBL28815718 | 0.89 | DPP7 (0.43) | DPP7KMT2ACYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL21412700 | 0.88 | KMT2A (0.50) | DPP7KMT2ASIGMAR1MAP4K4ATR | |
| SCHEMBL3165932 | 0.81 | DPP7 (0.82) | DPP7KMT2ASIGMAR1CYP2D6CYP3A4 | |
| SCHEMBL2231823 | 0.80 | CYP3A4 (0.43) | KMT2ACYP2D6CYP3A4 | |
| SCHEMBL3577555 | 0.80 | DPP7 (0.70) | DPP7KMT2ASIGMAR1MAP4K4CYP2D6 | |
| SCHEMBL28481490 | 0.79 | KMT2A (0.52) | DPP7KMT2ASIGMAR1MAP4K4CYP2D6 | |
| SCHEMBL3171554 | 0.79 | DPP7 (0.79) | DPP7KMT2ASIGMAR1CYP2D6CYP3A4 | |
| SCHEMBL21412626 | 0.76 | KMT2A (0.54) | DPP7KMT2ASIGMAR1ATR | |
| SCHEMBL1035345 | 0.76 | ALDH1A1 (0.56) | CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774734-A1 | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE | Elex Biotech, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019191502-A1 | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE | ELEX BIOTECH, INC. (US) | 2019-10-03 | — | — | WO | disclosed |