SCHEMBL21414239

SCHEMBL21414239

Cc1ccccc1-c1ccc2c3ccccc3n(-c3cc(C#N)cc(-n4c5ccccc5c5ccc(-c6ccccc6C)cc54)c3-c3cc(C#N)cc(C#N)c3)c2c1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.38
SMYD2 Q9NRG4 1/20 0.34
GRIA2 P42262 1/20 0.33
GRIA4 P48058 1/20 0.33
PDE9A O76083 1/20 0.33
PDE1C Q14123 1/20 0.33
TRPA1 O75762 1/20 0.32
PTGER4 P35408 1/20 0.31
HTR1A P08908 1/20 0.30
HTR7 P34969 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C19 P33261 1/20 0.30
CLK4 Q9HAZ1 1/20 0.30
CHEK1 O14757 1/20 0.30
IMPDH2 P12268 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21414117 0.96 AR (0.40) ARSMYD2GRIA2GRIA4TRPA1
SCHEMBL21414116 0.93 AR (0.38) ARSMYD2GRIA2GRIA4PDE9A
SCHEMBL21546687 0.92 ADRA2C (0.36) ARSMYD2GRIA2GRIA4PTGER4
SCHEMBL19909383 0.91 AR (0.35) ARSMYD2GRIA2GRIA4PDE9A
SCHEMBL22564398 0.91 AR (0.42) ARSMYD2GRIA2GRIA4
SCHEMBL21414104 0.90 PDE9A (0.35) PDE9APDE1C
SCHEMBL25658931 0.90 AR (0.40) ARSMYD2GRIA2GRIA4TRPA1
SCHEMBL21414121 0.90 AR (0.40) ARSMYD2GRIA2GRIA4TRPA1
SCHEMBL19909333 0.89 MAPK14 (0.37) ARGRIA2GRIA4ALDH1A1CYP1A2
SCHEMBL19903541 0.89 AR (0.42) ARGRIA2GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3385264-B1 ORGANIC MOLECULES, IN PARTICULAR FOR THE APPLICATION IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-10-02 EP disclosed