Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.42 |
| ▸ | CCND3 | P30281 | 13/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.41 |
| ▸ | CDK2 | P24941 | 12/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.41 |
| ▸ | CDK1 | P06493 | 8/20 | 0.41 |
| ▸ | CDK7 | P50613 | 8/20 | 0.41 |
| ▸ | CDK9 | P50750 | 8/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20203553 | 0.89 | CDK4 (0.48) | CDK4CCND3CDK6CDK2CCNA2 | |
| SCHEMBL18291660 | 0.79 | CDK4 (0.44) | CDK4CCND3CDK6CDK2CCNA2 | |
| SCHEMBL20038551 | 0.78 | CDK4 (0.42) | CDK4CCND3CDK6CDK2CCNA2 | |
| SCHEMBL20203445 | 0.78 | CDK4 (0.39) | CDK4CCND3CDK6CDK2CCNA2 | |
| SCHEMBL20249391 | 0.76 | CDK4 (0.42) | CDK4CCND3CDK6CDK2CCNA2 | |
| SCHEMBL23733449 | 0.73 | PNMT (0.42) | CDK4CCND3CDK6CDK2CDK1 | |
| SCHEMBL18806168 | 0.73 | PDCD1 (0.47) | CDK4CCND3CDK6CDK2CDK1 | |
| SCHEMBL21414456 | 0.71 | CDK1 (0.44) | CDK4CDK6CDK2CDK1CDK7 | |
| SCHEMBL20203452 | 0.71 | FLT3 (0.47) | CDK4CCND3JAK2LMNAMAPT | |
| SCHEMBL20203454 | 0.71 | CDK4 (0.39) | CDK4CCND3CDK6CDK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546458-B1 | ((PYRIDIN-2-YL)-AMINO)PYRIDO[3,4-D]PYRIMIDINE AND ((PYRIDAZIN-3-YL)-AMINO)PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES AS CDK4/6 INHIBITORS FOR TREATING E.G. RHEUMATOID ARTHRITIS, ARTERIOSCLEROSIS, PULMONARY FIBROSIS, CEREBRAL INFARCTION OR CANCER | TEIJIN PHARMA LTD (JP) | 2021-01-06 | — | — | EP | disclosed |
| EP-3546458-A1 | PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2019-10-02 | — | — | EP | disclosed |