Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 17/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21415768 | 0.90 | RORC (0.62) | RORCMAPK1ROCK2ROCK1 | |
| SCHEMBL21415915 | 0.88 | RORC (0.56) | RORC | |
| SCHEMBL17695906 | 0.86 | RORC (0.74) | RORC | |
| SCHEMBL17695822 | 0.86 | RORC (0.74) | RORC | |
| SCHEMBL21415911 | 0.85 | RORC (0.78) | RORCMAPK1ROCK2ROCK1 | |
| SCHEMBL21415829 | 0.84 | RORC (0.56) | RORCMAPK1ROCK2ROCK1 | |
| SCHEMBL21415871 | 0.83 | RORC (0.48) | RORCMAPK1ROCK2ROCK1 | |
| SCHEMBL21415749 | 0.83 | RORC (0.48) | RORCMAPK1ROCK2ROCK1 | |
| SCHEMBL21415812 | 0.79 | RORC (0.43) | RORCMAPK1ROCK2ROCK1 | |
| SCHEMBL21415897 | 0.76 | RORC (0.46) | RORCMAPK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207043-B3 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | VITAE PHARMACEUTICALS LLC (US) | 2019-10-02 | — | — | EP | disclosed |