Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 14/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.46 |
| ▸ | KIT | P10721 | 9/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491730 | 0.90 | LCK (0.55) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL5494660 | 0.85 | LCK (0.64) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL42089 | 0.80 | LCK (0.73) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL28298101 | 0.77 | LCK (0.69) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL5489026 | 0.72 | LCK (0.55) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL5488838 | 0.72 | MAP4K4 (0.61) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL8129675 | 0.72 | FGFR1 (0.82) | SRCFGFR1FGFR4PDGFRAPDGFRB | |
| SCHEMBL2846087 | 0.71 | BIRC5 (0.55) | KDRSRCFGFR1PDGFRAPDGFRB | |
| SCHEMBL2741576 | 0.71 | LCK (0.65) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL2850180 | 0.71 | FABP3 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |