Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.69 |
| ▸ | JAK3 | P52333 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.69 |
| ▸ | BACE1 | P56817 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | DHFR | P00374 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491016 | 0.84 | LCK (0.56) | LCKJAK3KDRMAPK14BACE1 | |
| SCHEMBL5494572 | 0.84 | LCK (0.56) | LCKJAK3KDRMAPK14BACE1 | |
| SCHEMBL5491730 | 0.83 | LCK (0.55) | LCKJAK3KDRMAPK14BACE1 | |
| SCHEMBL5494575 | 0.82 | LCK (1.00) | LCKJAK3KDRMAPK14BACE1 | |
| SCHEMBL41115 | 0.81 | LCK (0.53) | LCKJAK3KDRMAPK14BACE1 | |
| SCHEMBL2741576 | 0.79 | LCK (0.65) | LCKJAK3KDRMAPK14BACE1 | |
| SCHEMBL5494660 | 0.78 | LCK (0.64) | LCKJAK3KDRMAPK14ABL1 | |
| SCHEMBL41400 | 0.78 | LCK (0.53) | LCKJAK3KDRMAPK14ADORA1 | |
| SCHEMBL21416857 | 0.77 | LCK (0.49) | LCKJAK3KDRMAPK14ABL1 | |
| SCHEMBL5492624 | 0.77 | LCK (0.59) | LCKJAK3KDRMAPK14BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843858-A | Certain chemical entities, composition and method | 润新生物公司 | 2019-06-04 | — | — | CN | disclosed |