Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 10/20 | 0.52 |
| ▸ | DHPS | P49366 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21417038 | 0.84 | CHRNA7 (0.50) | CHRNA7TACR2HTR3AOPRM1HDAC1 | |
| SCHEMBL21417016 | 0.79 | CHRNA7 (0.54) | CHRNA7OPRM1HDAC1HDAC3HDAC4 | |
| SCHEMBL21417050 | 0.79 | CHRNA7 (0.54) | CHRNA7HTR3AOPRM1HDAC1HDAC3 | |
| SCHEMBL20661376 | 0.78 | CHRNA7 (0.50) | CHRNA7UTS2RHTR3AOPRM1NPC1 | |
| SCHEMBL20618266 | 0.78 | CHRNA7 (0.54) | CHRNA7DHPSUTS2RHTR3AHDAC1 | |
| SCHEMBL21417023 | 0.73 | CHRNA7 (0.53) | CHRNA7HTR3AHDAC1HDAC3HDAC4 | |
| SCHEMBL21417331 | 0.73 | CHRNA7 (0.52) | CHRNA7HTR3AOPRM1HDAC1HDAC3 | |
| SCHEMBL18264115 | 0.72 | CHRNA1 (0.57) | CHRNA7DHPSUTS2RHTR3ANPC1 | |
| SCHEMBL18264114 | 0.72 | CHRNA1 (0.57) | CHRNA7DHPSUTS2RHTR3ANPC1 | |
| SCHEMBL21417305 | 0.71 | HDAC3 (0.59) | CHRNA7HTR3AHDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233087-B1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | AXOVANT SCIENCES GMBH (DE) | 2019-10-02 | — | — | EP | disclosed |