Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.76 |
| ▸ | USP2 | O75604 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.76 |
| ▸ | NT5E | P21589 | 2/20 | 0.76 |
| ▸ | TOP2A | P11388 | 2/20 | 0.76 |
| ▸ | RELA | Q04206 | 1/20 | 0.76 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.70 |
| ▸ | ALB | P02768 | 2/20 | 0.69 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.69 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | GLI1 | P08151 | 1/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.69 |
| ▸ | DPP4 | P27487 | 1/20 | 0.69 |
| ▸ | RORC | P51449 | 1/20 | 0.69 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.69 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 4/20 | 0.67 |
| ▸ | CES2 | O00748 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16994315 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL13573802 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL15120375 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL16983599 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL2733084 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL13098063 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL6112842 | 1.00 | PTPN1 (0.76) | PTPN1USP2LMNAHIF1ANT5E | |
| Water SCHEMBL8586171 | 0.99 | PTPN1 (0.75) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL210109 | 0.93 | PTPN1 (0.73) | PTPN1USP2LMNAHIF1ANT5E | |
| SCHEMBL5956480 | 0.92 | PTPN1 (0.72) | PTPN1USP2LMNAHIF1ANT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117003604-A | Synthesis method and flow of allyl fluoroalkyl compound | 武汉大学 | 2023-11-07 | — | — | CN | claimed |
| US-20040087560-A1 | Leukemia; anticancer agents; antiproliferative agents | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2004-05-06 | — | — | US | claimed |
| US-6369109-B1 | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor | DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS (DE) | 2002-04-09 | — | — | US | claimed |
| EP-1124842-A1 | BETULINIC ACID AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF NEUROECTODERMAL TUMORS | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2001-08-22 | — | — | EP | claimed |
| WO-2000024762-A1 | BETULINIC ACID AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF NEUROECTODERMAL TUMORS | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2000-05-04 | — | — | WO | claimed |
| CN-117003604-A | Synthesis method and flow of allyl fluoroalkyl compound | 武汉大学 | 2023-11-07 | — | — | CN | disclosed |
| US-9340513-B2 | Propenoate derivatives of betulin | GLAXOSMITHKLINE LLC (US) | 2016-05-17 | — | — | US | disclosed |
| US-8969395-B2 | Triterpenoid derivatives useful as antiproliferative agents | UNIVERSIDADE DE COIMBRA (PT) | 2015-03-03 | — | — | US | disclosed |
| US-20140350032-A1 | PROPENOATE DERIVATIVES OF BETULIN | GLAXOSMITHKLINE LLC | 2014-11-27 | — | — | US | disclosed |
| EP-1484375-B2 | Resin acid composition and use thereof | FORCHEM OY (FI) | 2014-07-23 | — | — | EP | disclosed |
| EP-2125860-B1 | METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN | UNIVERZITA KARLOVA V PRAZE PRIRODOVEDECKA FAKULTA (CZ) | 2012-12-19 | — | — | EP | disclosed |
| US-20120129901-A1 | TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | UNIVERSIDADE DE COIMBRA (PT) | 2012-05-24 | — | — | US | disclosed |
| US-6369109-B1 | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor | DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS (DE) | 2002-04-09 | — | — | US | disclosed |
| WO-2001090046-A1 | TRITERPENOID DERIVATIVES | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2001-11-29 | — | — | WO | disclosed |
| EP-1124842-A1 | BETULINIC ACID AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF NEUROECTODERMAL TUMORS | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000024762-A1 | BETULINIC ACID AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF NEUROECTODERMAL TUMORS | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2000-05-04 | — | — | WO | disclosed |
| EP-0988311-A1 | BETULINOL DERIVATIVES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998055497-A1 | BETULINOL DERIVATIVES | CORNELL RESEARCH FOUNDATION, INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998043936-A2 | IMPROVED METHODS OF MANUFACTURING BETULINIC ACID | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1998-10-08 | — | — | WO | disclosed |
| US-5804575-A | Methods of manufacturing betulinic acid | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1998-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350032-A1 | PROPENOATE DERIVATIVES OF BETULIN | BET1, TMPO, PGGT1B | PTPN1 1792/4885USP2 4748/4885LMNA 3690/4885 |
| US-20040087560-A1 | Leukemia; anticancer agents; antiproliferative agents | MCL1, MKI67, CCNA1 | PTPN1 809/4885USP2 4014/4885LMNA 1681/4885 |
| US-20120129901-A1 | TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | ALPI, LSS, CYP46A1 | PTPN1 3105/4885USP2 3233/4885LMNA 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.