Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 19/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 14/20 | 0.45 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27118054 | 0.91 | CSF1R (0.46) | CSF1RPDGFRAKITMETKDR | |
| SCHEMBL27117578 | 0.90 | CSF1R (0.43) | CSF1RPDGFRAKITMETKDR | |
| SCHEMBL21882323 | 0.89 | CSF1R (0.47) | CSF1RPDGFRAKITMETKDR | |
| SCHEMBL21882299 | 0.86 | CSF1R (0.42) | CSF1RPDGFRAKITMETPDGFRB | |
| SCHEMBL21882322 | 0.86 | CSF1R (0.61) | CSF1RPDGFRAKITMETPDGFRB | |
| SCHEMBL21425633 | 0.86 | CSF1R (0.63) | CSF1RPDGFRAKITMETPDGFRB | |
| SCHEMBL21882568 | 0.85 | CSF1R (0.46) | CSF1RPDGFRAKITMETKDR | |
| SCHEMBL22729051 | 0.85 | CSF1R (0.59) | CSF1RPDGFRAKITMETKDR | |
| SCHEMBL22728929 | 0.85 | CSF1R (0.60) | CSF1RPDGFRAKITMETPDGFRB | |
| SCHEMBL21882211 | 0.83 | CSF1R (0.51) | CSF1RPDGFRAKITMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632907-B1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2024-02-28 | — | — | EP | disclosed |
| EP-3632907-A1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |