Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214643 | 0.69 | ALDH1A1 (0.41) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL214645 | 0.68 | ALDH1A1 (0.41) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL214644 | 0.67 | MEN1 (0.39) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5935382 | 0.66 | HRH3 (0.53) | HRH3HRH1 | |
| SCHEMBL3586261 | 0.64 | HRH3 (0.56) | HRH3HRH1HRH2 | |
| SCHEMBL7247185 | 0.64 | HRH3 (0.60) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4235138 | 0.62 | MAOB (0.60) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3986277 | 0.62 | HRH2 (0.46) | ALDH1A1MAPTKMT2ASMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL5935401 | 0.62 | MAOB (0.59) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4229987 | 0.61 | MAOB (0.58) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |