Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.55 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ATF4 | P18848 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21439777 | 0.94 | NPSR1 (0.61) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21436718 | 0.84 | NPSR1 (0.55) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21450365 | 0.82 | MEN1 (0.51) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21436466 | 0.79 | MEN1 (0.53) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21450180 | 0.78 | MAPT (0.68) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL16082990 | 0.77 | MEN1 (0.85) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2610071 | 0.77 | MEN1 (0.85) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21450201 | 0.77 | MAPT (0.73) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21436739 | 0.75 | MEN1 (0.60) | NPSR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21436991 | 0.74 | NPSR1 (0.77) | NPSR1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193540-A1 | HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |