Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NPY1R | P25929 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.56 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21450201 | 0.83 | MAPT (0.73) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21439777 | 0.83 | NPSR1 (0.61) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21436734 | 0.78 | NPSR1 (0.56) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL29130878 | 0.78 | NPC1 (0.57) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21450360 | 0.77 | RAB9A (0.83) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2683107 | 0.77 | NPC1 (0.76) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21436718 | 0.77 | NPSR1 (0.55) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21436991 | 0.75 | NPSR1 (0.77) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL21450182 | 0.75 | PDE5A (0.69) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL16082990 | 0.75 | MEN1 (0.85) | MAPTRAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193540-A1 | HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |