Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL908949 | 0.82 | MERTK (0.72) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL29364631 | 0.82 | MERTK (0.72) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL10740434 | 0.80 | TXNRD1 (0.58) | HTTTXNRD1MAPTMAPK1NPSR1 | |
| SCHEMBL29983153 | 0.80 | MERTK (0.49) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL15514986 | 0.80 | MERTK (0.49) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL31104588 | 0.79 | MERTK (0.48) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL30666117 | 0.79 | MERTK (0.48) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL1029176 | 0.79 | MERTK (0.48) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL27175935 | 0.79 | MERTK (0.48) | MERTKALDH1A1HTTTXNRD1TDP1 | |
| SCHEMBL26868877 | 0.79 | MERTK (0.48) | MERTKALDH1A1HTTTXNRD1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193540-A1 | HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019193540-A1 | HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |