Sugi Predict

Sugi Predict / Targets / TXNRD1

TXNRD1

Thioredoxin reductase 1, cytoplasmic · Q16881 · TXNRD1 on Sugi Atlas →

17,337 patent compounds predicted against TXNRD1, 10,154 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1162351 SCHEMBL1162351 0.52 19/20
SCHEMBL228399 SCHEMBL228399 0.57 18/20
SCHEMBL336303 SCHEMBL336303 0.56 18/20
SCHEMBL225571 SCHEMBL225571 0.55 18/20
SCHEMBL621047 SCHEMBL621047 0.54 18/20
SCHEMBL226229 SCHEMBL226229 0.44 13/20
SCHEMBL908949 SCHEMBL908949 0.43 8/20
Gamma-Cyclodextrin Gamma-Cyclodextrin (SCHEMBL8768) 0.77 6/20
Betadex Betadex (SCHEMBL24215) 0.77 6/20
Alfadex Alfadex (SCHEMBL24981) 0.77 6/20
Betadex Betadex (SCHEMBL127367) 0.77 6/20
Gamma-Cyclodextrin Gamma-Cyclodextrin (SCHEMBL180792) 0.77 6/20
Alfadex Alfadex (SCHEMBL181370) 0.77 6/20
Betadex Betadex (SCHEMBL434559) 0.77 6/20
SCHEMBL466130 SCHEMBL466130 0.77 6/20
Betadex Betadex (SCHEMBL692932) 0.74 6/20
Betadex Betadex (SCHEMBL441667) 0.61 6/20
SCHEMBL890314 SCHEMBL890314 0.59 6/20
SCHEMBL1193222 SCHEMBL1193222 0.59 6/20
SCHEMBL398655 SCHEMBL398655 0.53 6/20

Clinical trials — most relevant to TXNRD1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept PHASE3COMPLETED
Cysteine Supplementation in Critically Ill Neonates PHASE2/PHASE3UNKNOWN
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy PHASE2RECRUITING
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD PHASE2COMPLETED
A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta PHASE1COMPLETED
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels PHASE1COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease EARLY_PHASE1RECRUITING
Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery nanCOMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise nanCOMPLETED
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) nanRECRUITING
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects nanCOMPLETED
Correlation Research of Thioredoxin Reductase in Lung Cancer nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis nanCOMPLETED
Tecfidera Diffusion Tensor Imaging nanCOMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility nanCOMPLETED
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults. nanNOT_YET_RECRUITING
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients nanUNKNOWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Effect of Protein on Endoplasmic Reticulum Stress nanNOT_YET_RECRUITING
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults nanCOMPLETED
Mitochondrial Function of Immune Cells in Sepsis nanCOMPLETED
ADAPT: Efficacy of a Dietary Supplement During and After Exercise nanCOMPLETED
Comparison of Oxidants and Antioxidants in Breastmilk Under Different Anesthesia Protocols nanCOMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea nanRECRUITING
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS nanRECRUITING
Diabetic Cardiomyopathy and Heart Failure nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a TXNRD1 binder may also engage these)

ProteinNameSimilarity
O62768 — 0.998 O62768 →
P91938 — 0.996 P91938 →
P39050 — 0.996 P39050 →
Q5NVA2 — 0.996 Q5NVA2 →
Q17745 — 0.996 Q17745 →
TXNRD3 Thioredoxin reductase 3 0.995 landscape →
Q9MYY8 — 0.994 Q9MYY8 →
Q43154 — 0.994 Q43154 →
P39051 — 0.993 P39051 →
Q9VNT5 — 0.993 Q9VNT5 →
P13110 — 0.993 P13110 →
P28593 — 0.993 P28593 →
O89049 — 0.993 O89049 →
Q9JLT4 — 0.992 Q9JLT4 →
Q99MD6 — 0.992 Q99MD6 →
P48642 — 0.992 P48642 →
TXNRD2 Thioredoxin reductase 2, mitochondrial 0.991 landscape →
Q43621 — 0.990 Q43621 →
Q8S3R2 — 0.990 Q8S3R2 →
P42770 — 0.989 P42770 →
P30635 — 0.989 P30635 →
P80461 — 0.989 P80461 →
P27456 — 0.989 P27456 →
P48641 — 0.988 P48641 →
Q84PW3 — 0.988 Q84PW3 →
Q9LK94 — 0.988 Q9LK94 →
P00927 — 0.988 P00927 →
P48640 — 0.988 P48640 →
P70619 — 0.987 P70619 →
Q10499 — 0.987 Q10499 →