Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 20/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 20/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 20/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145828 | 0.92 | HDAC1 (0.45) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1367543 | 0.81 | HDAC6 (0.41) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL4539202 | 0.76 | HDAC1 (0.60) | HDAC1 | |
| SCHEMBL2143881 | 0.75 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1365585 | 0.73 | HDAC6 (0.46) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1365417 | 0.70 | HDAC1 (0.57) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL12142364 | 0.68 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1366934 | 0.68 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL4540562 | 0.68 | HDAC1 (0.59) | HDAC1 | |
| SCHEMBL7997961 | 0.67 | HDAC6 (0.55) | HDAC3HDAC1HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489657-A2 | Inhibitors of histone deacetylase | MethylGene Inc. (CA) | 2012-08-22 | — | — | EP | disclosed |
| EP-2343286-A1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2011-07-13 | — | — | EP | disclosed |