SCHEMBL2145828

SCHEMBL2145828

O=C(NO)c1cnc(N2C[C@]3(Cc4cccnc4)C[C@H]2CN3C(=O)O)nc1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 14/20 0.45
HDAC6 Q9UBN7 14/20 0.45
HDAC2 Q92769 13/20 0.45
HDAC3 O15379 11/20 0.45
HDAC8 Q9BY41 10/20 0.42
HDAC4 P56524 8/20 0.42
HDAC7 Q8WUI4 8/20 0.42
HDAC10 Q969S8 8/20 0.42
HDAC11 Q96DB2 8/20 0.42
HDAC9 Q9UKV0 8/20 0.42
HDAC5 Q9UQL6 8/20 0.42
VNN1 O95497 3/20 0.37
GPR132 Q9UNW8 1/20 0.36
CYP2D6 P10635 1/20 0.35
KCNH2 Q12809 1/20 0.35
CYP17A1 P05093 1/20 0.35
CYP19A1 P11511 1/20 0.35
HSD11B1 P28845 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2144010 0.92 HDAC3 (0.48) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL1367543 0.77 HDAC6 (0.41) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL2143881 0.72 HDAC3 (0.40) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL1365585 0.69 HDAC6 (0.46) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL1367752 0.68 HDAC1 (0.53) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL4556792 0.68 HDAC1 (0.53) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL1367756 0.68 HDAC1 (0.53) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL16302081 0.67 HDAC1 (0.48) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL16566450 0.67 HDAC6 (0.41) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL1365417 0.64 HDAC1 (0.57) HDAC1HDAC6HDAC2HDAC3HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2343286-A1 Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase Methylgene, Inc. (CA) 2011-07-13 EP disclosed