Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15727746 | 0.89 | HSD17B10 (0.75) | HSD17B10RXFP1ALDH1A1CYP2C9HPGD | |
| SCHEMBL10113960 | 0.78 | HSD17B10 (0.72) | HSD17B10RXFP1ALDH1A1CYP2C9HPGD | |
| SCHEMBL17486884 | 0.77 | ADORA2B (0.58) | RXFP1ALDH1A1MAPTTSHR | |
| SCHEMBL17486881 | 0.77 | ADORA2B (0.60) | RXFP1ALDH1A1MAPTTSHR | |
| SCHEMBL19499803 | 0.77 | ADORA2B (0.60) | RXFP1ALDH1A1MAPTTSHR | |
| SCHEMBL19499801 | 0.77 | ADORA2B (0.60) | RXFP1ALDH1A1MAPTTSHR | |
| SCHEMBL19677779 | 0.75 | ADORA2B (0.49) | RXFP1ALDH1A1MAPT | |
| SCHEMBL17200781 | 0.74 | RXFP1 (0.68) | HSD17B10RXFP1ALDH1A1CYP2C9HPGD | |
| SCHEMBL17486888 | 0.73 | ADORA2B (0.51) | RXFP1ALDH1A1MAPT | |
| SCHEMBL18166765 | 0.73 | HSD17B10 (0.78) | HSD17B10RXFP1ALDH1A1CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922832-B1 | GLUTAMINASE INHIBITORS AND METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |