Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.41 |
| ▸ | JAK3 | P52333 | 10/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144840 | 0.91 | JAK2 (0.46) | JAK2JAK3PTK2JAK1SCN9A | |
| SCHEMBL3300834 | 0.85 | JAK2 (0.42) | JAK2JAK3PTK2JAK1SCN9A | |
| SCHEMBL3302340 | 0.83 | JAK2 (0.42) | JAK2JAK3PTK2JAK1CTSS | |
| SCHEMBL3303365 | 0.82 | SCN9A (0.44) | JAK2JAK3PTK2JAK1HTR2A | |
| SCHEMBL2144682 | 0.81 | JAK2 (0.43) | JAK2JAK3PTK2JAK1SCN9A | |
| SCHEMBL2145026 | 0.81 | PTK2 (0.48) | JAK2JAK3PTK2JAK1CTSS | |
| SCHEMBL2145005 | 0.79 | JAK2 (0.47) | JAK2JAK3PTK2JAK1CTSS | |
| SCHEMBL2145387 | 0.78 | PTK2 (0.46) | JAK2JAK3PTK2JAK1CTSS | |
| SCHEMBL2144608 | 0.77 | JAK2 (0.41) | JAK2JAK3PTK2JAK1SCN9A | |
| SCHEMBL2144333 | 0.77 | JAK2 (0.41) | JAK2JAK3PTK2JAK1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |