Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 13/20 | 0.46 |
| ▸ | JAK2 | O60674 | 13/20 | 0.46 |
| ▸ | JAK3 | P52333 | 12/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145026 | 0.96 | PTK2 (0.48) | PTK2JAK2JAK3CTSSCTSK | |
| SCHEMBL2144584 | 0.91 | JAK2 (0.46) | PTK2JAK2JAK3JAK1 | |
| SCHEMBL2145005 | 0.90 | JAK2 (0.47) | PTK2JAK2JAK3CTSSCTSK | |
| SCHEMBL2144500 | 0.90 | JAK2 (0.46) | PTK2JAK2JAK3IDH2JAK1 | |
| SCHEMBL2144840 | 0.85 | JAK2 (0.46) | PTK2JAK2JAK3CTSSCTSK | |
| SCHEMBL3300834 | 0.85 | JAK2 (0.42) | PTK2JAK2JAK3CTSSCTSK | |
| SCHEMBL2143973 | 0.84 | JAK2 (0.51) | PTK2JAK2JAK3JAK1 | |
| SCHEMBL2145289 | 0.83 | JAK2 (0.46) | PTK2JAK2JAK3JAK1 | |
| SCHEMBL2144031 | 0.82 | JAK2 (0.44) | PTK2JAK2JAK3IDH2JAK1 | |
| SCHEMBL2144682 | 0.82 | JAK2 (0.43) | PTK2JAK2JAK3CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |