Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 13/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15727658 | 0.94 | GLS (0.76) | GLSL3MBTL1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL21443376 | 0.88 | GLS (0.88) | GLS | |
| SCHEMBL14987543 | 0.87 | GLS (0.78) | GLSL3MBTL1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15724907 | 0.86 | GLS (0.78) | GLSL3MBTL1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL21443326 | 0.86 | GLS (0.59) | GLSL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21443335 | 0.85 | GLS (0.59) | GLSL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21443424 | 0.83 | GLS (0.69) | GLSALDH1A1POLBRAB9A | |
| SCHEMBL21443454 | 0.81 | GLS (0.61) | GLS | |
| SCHEMBL17432944 | 0.81 | GLS (1.00) | GLS | |
| SCHEMBL15727681 | 0.81 | GLS (0.78) | GLSALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922832-B1 | GLUTAMINASE INHIBITORS AND METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |